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KMID : 0361020010440090930
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Korean Journal of Otolaryngology - Head and Neck Surgery
2001 Volume.44 No. 9 p.930 ~ p.935
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Effects of Dexamethasone on RANTES Expression of Nasal Fibroblast
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진영완/Young Wan Jin
조중생/김훈/김춘동/진성용/차장일/Joong Seang Cho/Hoon Kim/Chun Dong Kim/Soung Yong Jin/Chang Il Cha
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Abstract
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Background and Objectives : Fibroblasts play an indirectly augmenting effector role in allergic inflammatory response by releasing different proinflammatory cytokines, including RANTES, GM-CSF, IL-i after stimulation by other inflammatory
cytokines
such
as IFN-γ and TNF-α. The aim of this study was to investigate expression of RANTES in allergic and non-allergic nasal fibroblasts after stimulation with IFN-γ and TNF-α, and to study the effect of dexamethasone on the RANTES expression of
nasal
fibroblast cell. Materials and Methods : Using the 3rd passage of fibroblasts taken from the inferior turbinates of allergic and non-allergic patients, we evaluated the RANTES expression of fibroblasts after the IFN-γ, TNF-α stimulation in the
presence or in the absence of dexamethasone by ELISA. Results : The expression of RANTES in allergic nasal fibroblasts stimulated by cytokines was stronger than in non-allergic nasal fibroblasts stimulated by cytokines, And dexamethasone
suppressed
the
RANTES expression in allergic nasal fibroblasts stimulated by IFN-γ. However, dexamethasone did not affect the RANTES expression in allergic fibroblasts stimulated by TNF-α and non-allergic fibroblasts stimulated by IFN-γ and TNF-α .
Conclusion
:
This study shows different responses of the RANTES production in nasal fibroblasts to dexamethasone, perhaps reflecting heterogeneity of nasal fibroblasts.
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KEYWORD
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